preterm birth

Altered cortical gyrification in adults who were born very preterm and its associations with cognition and mental health

Background The last trimester of pregnancy is a critical period for the establishment of cortical gyrification, and altered folding patterns have been reported following very preterm birth (textless 33 weeks of gestation) in childhood and …

Systematic assessment of perinatal and socio-demographic factors associated with IQ from childhood to adult life following very preterm birth

Objective To construct a comprehensive model of predictors of IQ and its developmental trajectories in survivors of very preterm birth from childhood to adult life. Methods We examined trajectories of Full-scale, Verbal and Performance IQ from age 8 …

Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm

Language difficulties have been reported in children and adolescents who were born very preterm (textless32 weeks’ gestation) and associated with an atypical lateralization of language processing, i.e., increased right-hemispheric engagement. This …

A dimensional approach to assessing psychiatric risk in adults born very preterm

BackgroundIndividuals who were born very preterm have higher rates of psychiatric diagnoses compared with term-born controls; however, it remains unclear whether they also display increased sub-clinical psychiatric symptomatology. Hence, our …

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

We discovered that people who had brain injury associated with very preterm birth has reduced dopamine function and smaller hippocampus than controls. The dopamine dysfunction was associated with negative and cognitive psychiatric symptoms. This work …

Real-Life Impact of Executive Function Impairments in Adults Who Were Born Very Preterm

Objectives: Children and adolescents who were born very preterm (≤32 weeks’ gestation) are vulnerable to experiencing cognitive problems, including in executive function. However, it remains to be established whether cognitive deficits are evident in …

White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions

Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between …

Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation

Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm

Background Very preterm birth (VPT; textless32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not …

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Deficits in memory function have been described in children and adolescents who were born very preterm (VPT), which can have profound effects on their school achievement and everyday life. However, to date, little is known about the development of …