brain injury

Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain

The brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. However, we know very little about why plasticity occurs in some areas of the brain, and not others. Here we investigated how the …

The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning

We know the hippocampus is important for memory, but many of the lesion studies in humans and non-human primates investigating the role of the hippocampus in memory have also affected other related structures. Studies in rodents can overcome this …

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

We discovered that people who had brain injury associated with very preterm birth has reduced dopamine function and smaller hippocampus than controls. The dopamine dysfunction was associated with negative and cognitive psychiatric symptoms. This work …

White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions

Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between …

Plasticity in the Working Memory System: Life Span Changes and Response to Injury

Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study

Children who have brain injury following preterm birth often have working memory problems. When we assessed adults with the same injury, we found they no longer had severe working memory difficulties. By combining techniques to investigate the …

Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream

Assessment of brain-damaged subjects presenting with dissociated repetition deficits after selective injury to either the left dorsal or ventral auditory pathways can provide further insight on their respective roles in verbal repetition. We …

Repeating with the right hemisphere: reduced interactions between phonological and lexical-semantic systems in crossed aphasia?

Knowledge on the patterns of repetition amongst individuals who develop language deficits in association with right hemisphere lesions (crossed aphasia) is very limited. Available data indicate that repetition in some crossed aphasics experiencing …

Prognostic value of cortically induced motor evoked activity by TMS in chronic stroke: Caveats from a revealing single clinical case

We report the case of a chronic stroke patient (62 months after injury) showing total absence of motor activity evoked by transcranial magnetic stimulation (TMS) of spared regions of the left motor cortex, but near-to-complete recovery of motor …

Recovery from Post-stroke Aphasia: Lessons from Brain Imaging and Implications for Rehabilitation and Biological Treatments

Aphasia, a condition defined as the partial or complete loss of language function after brain damage, is one of the most devastating cognitive deficits produced by stroke lesions. Over the past decades, there have been great advances in the diagnosis …